CTAOP's mission is to help keep African youth safe from HIV/AIDS.
The project is committed to supporting community-engaged organizations that address the key drivers of the disease.
In the same year, she starred in the financially unsuccessful science fiction thriller Aeon Flux.
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In 2017, Theron starred in The Fate of the Furious, where she played Cipher, who is the main antagonist of the entire The Fast and the Furious series, and in Atomic Blonde, an adaptation of the graphic novel The Coldest City, directed by David Leitch.
The Charlize Theron Africa Outreach Project (CTAOP) was created in 2007 by Theron, who the next year was named a UN Messenger of Peace, in an effort to support African youth in the fight against HIV/AIDS.
She also appeared on the cover of the May 1999 issue of Playboy magazine, in photos taken several years earlier when she was an unknown model; Theron unsuccessfully sued the magazine for publishing them without her consent.
She starred in five films in 2000: Reindeer Games, The Yards, The Legend of Bagger Vance and Men of Honor, Sweet November and was briefly considered a new "It girl".
Although the geographic scope of CTAOP is Sub-Saharan Africa, the primary concentration has mostly been Charlize's home country of South Africa.
CTAOP's approach is based on the belief that community-based organizations on the ground understand the social and structural relationships of their communities better than anyone.
(1996), The Devil's Advocate (1997), Mighty Joe Young (1998), The Cider House Rules (1999), The Italian Job (2003), Hancock (2008), The Road (2009), Snow White and the Huntsman (2012), Prometheus (2012), A Million Ways to Die in the West (2014), Mad Max: Fury Road (2015), The Fate of the Furious (2017), and Atomic Blonde (2017).
Theron received critical acclaim for her portrayal of serial killer Aileen Wuornos in Monster (2003), for which she won the Academy Award, Silver Bear, Golden Globe Award, and Screen Actors Guild Award for Best Actress among other accolades, becoming the first South African to win an Academy Award in a major acting category.
Theron has said of this period in her career that, "I kept finding myself in a place where directors would back me but studios didn't.
[I began] a love affair with directors, the ones I really, truly admired. Reindeer Games was not a good movie, but I did it because I loved John Frankenheimer." The Oscar win pushed her to The Hollywood Reporter's 2006 list of highest-paid actresses in Hollywood, earning US million for both her subsequent films, North Country and Aeon Flux, she ranked seventh, behind Halle Berry, Cameron Diaz, Drew Barrymore, Renée Zellweger, Reese Witherspoon and Nicole Kidman.
Following a two-year hiatus from the big screen, Theron returned to the spotlight in 2011 with Young Adult.